systemic inflammation leading to hepatic steatosis
Name (KEtitle)
Binding of agonist, Ionotropic glutamate receptors
Non-coding RNA expression profile alteration
Substance interaction with the lung resident cell membrane components
Inhibition, Mitochondrial Electron Transport Chain Complexes
Mitochondrial dysfunction EMPTY
Frustrated phagocytosis
Alkylation, Protein
Binding to ACE2
benzoquinone imine and acylglucuronide metabolites
Induced dysregulation of ACE2
Binding of inhibitor, NADH-ubiquinone oxidoreductase (complex I)
Interaction of α-diketones with arginine residues
Inhibition, IKK complex
Inhibition, Bile Salt Export Pump (ABCB11)
Inactivation of PPARγ
persistent, cytotoxicity (pleura or peritoneum)
Binding, Thiol/seleno-proteins involved in protection against oxidative stress
Endocytotic lysosomal uptake
Binding of antagonist, NMDA receptors
Activation, SREBF1
Increase, Cell injury/death
Neuroinflammation
Decreased, Neuronal network function in adult brain
Increased, Intracellular Calcium overload
Mitochondrial dysfunction
Emphysema
Pulmonary inflammation
Airway remodeling
Secondary genotoxicity
Increased, recruitment of inflammatory cells
Increase, Cytotoxicity (epithelial cells)
Increase, Cell Proliferation
Increased, DNA damage and mutation
Increased, Reactive oxygen species
Occurrence, renal proximal tubular necrosis
Inhibition, Nuclear factor kappa B (NF-kB)
Altered gene expression, NRF2 dependent antioxidant pathway
Increase in inflammation
Occurrence, Kidney toxicity
Oxidative Stress
Activation of ER stress
Hyperphosphorylation of Tau
Decrease of neuronal network function
Synaptic dysfunction
Impaired axonial transport
Accumulation, Cytosolic toxic Tau oligomers
Genomic instability
Increased activation, Nuclear factor kappa B (NF-kB)
Increased, secretion of proinflammatory mediators
Accumulation, Collagen
Increased Pro-inflammatory mediators
Activation, Stellate cells
Apoptotic cell death
IFNγ signaling
Increased inflammatory immune responses
Interferon-I antiviral response, antagonized by SARS-CoV-2
Toll Like Receptor (TLR) Dysregulation
Increased SARS-CoV-2 production
Increase, the risk of acute respiratory failure
Increase, Apoptosis
Binding of agonist, Angiotensin II receptor type 1 receptor (AT1R)
Impaired, Proteostasis
Degeneration of dopaminergic neurons of the nigrostriatal pathway
Fibroproliferative airway lesions
Epithelial Mesenchymal Transition
Increase, Inflammation
Activation, Caspase 8 pathway
Increase, proinflammatory mediators (TNFalpha)
Release, Cytokine
Production, Reactive oxygen species
Activation of specific nuclear receptors, Transcriptional change
Peptide Oxidation
Loss of alveolar capillary membrane integrity
Increased, activation of T (T) helper (h) type 2 cells
Increased, fibroblast proliferation and myofibroblast differentiation
Glutamate dyshomeostasis
Leukocyte recruitment/activation
Decreased, Calcium influx
Reduced levels of BDNF
Activation, AKT2
Overactivation, NMDARs
Apoptosis
Dysfunctional Autophagy
Activation of inflammation pathway
Fibroblast proliferation and differentiation
Decrease, Mitochondrial membrane potential
Immune cell activation
SARS-CoV-2 cell entry
Increased Angiotensin II
Inhibition, NADH-ubiquinone oxidoreductase (complex I)
Proteasomal dysfunction
Bile accumulation, Pathological condition
Activation of TGF-β signaling
Increased, inflammation
Decreased protection against oxidative stress
Disruption, Lysosome
Inhibition, NMDARs
Increased, Liver Steatosis
Impairment, Learning and memory
Chronic obstructive pulmonary disease
Lung cancer
Increased, Kidney Failure
Memory Loss
Increased, mesotheliomas
N/A, Liver fibrosis
Encephalitis
Immune mediated hepatitis
Increased Mortality
Parkinsonian motor deficits
Bronchiolitis obliterans
Liver Injury
Cholestasis, Pathology
Pulmonary fibrosis
N/A, Neurodegeneration
Liver
Group
Brain
Lung
Kidney
MIE
Type
KE
AO
Organ
KE level of organisation
Molecular
Cellular
Tissue
Individual
Population
Not specified
Cell/organ term
Neuron
Eukaryotic cell
Cell/organ
Pleura
Brain
Hepatocyte
microglial cell and astrocyte
Inflammatory cell, macrophage
Epithelial cell
Proximal tubule
T-cell
Kidney
Epithelial cell, tissue
Connective tissue
Hepatic stellate cell
eukaryotic cell
neural cell,brain
neural cell
neuron,brain
cell,organ
Liver
Overview of proinflammatory and profibrotic mediators
WPtitle
Neuroinflammation and glutamatergic signaling
miRNAs involved in DNA damage response
miRNA regulation of DNA damage response
Cytosolic DNA-sensing pathway
Nod-like receptor (NLR) signaling
Toll-like receptor signaling
TLR4 signaling and tolerance
Electron transport chain: OXPHOS system in mitochondria
Oxidative phosphorylation
Unfolded protein response
Cellular proteostasis
NRF2 pathway
NRF2-ARE regulation
DNA damage response
DNA damage response (only ATM dependent)
Soluble ACE2-mediated cell entry of SARS-CoV-2
Downregulation of ACE2 by SARS-CoV-2 spike protein
Mitochondrial complex I assembly model OXPHOS system
-
Canonical NF-kB pathway
Farnesoid X receptor pathway
Cholestasis
AMP-activated protein kinase signaling
PPAR signaling
Apoptosis
Glutathione metabolism
EGF/EGFR signaling
BDNF-TrkB signaling
White fat cell differentiation (WP4149)
Transcriptional cascade regulating adipogenesis
Focal adhesion: PI3K-Akt-mTOR-signaling
Cholesterol biosynthesis pathway in hepatocytes
Adipogenesis
Liver X receptor pathway
Neuroinflammation
mBDNF and proBDNF regulation of GABA neurotransmission
GABA receptor signaling
IL4 signaling
Airway smooth muscle cell contraction
IL9 signaling
Inflammatory response pathway
Cytokines and inflammatory response
MAPK signaling
IL1 signaling
Growth factors and hormones in beta cell proliferation
Oxidative stress response
Interleukin-1 induced activation of NF-kB
Molecular pathway for oxidative stress
Brain-derived neurotrophic factor (BDNF) signaling
Disruption of postsynaptic signaling by CNV
Axon guidance
Microtubule cytoskeleton regulation
DNA repair pathways, full network
Chemokine signaling
Cells and molecules involved in local acute inflammatory response
TGF-beta receptor signaling
Metabolic pathways of fibroblasts
Apoptosis modulation and signaling
Interferon-mediated signaling
Type II interferon signaling
Toll-like receptor signaling related to MyD88
SARS-CoV-2 replication organelle formation
Angiotensin II receptor type 1 pathway (Homo sapiens)
Cellular Proteostasis
TGF-beta signaling in thyroid cells for epithelial-mesenchymal transition
Complement activation
TNF-alpha signaling
Pregnane X receptor pathway
Wnt signaling
p53 transcriptional gene network
GPCRs, class C metabotropic glutamate, pheromone
Phosphatidyl inositol phosphate pathway
PI3K-Akt signaling
Ras signaling
Autophagy
Angiotensin II receptor type 1 pathway
Renin-angiotensin-aldosterone system (RAAS
Bile acid synthesis and enterohepatic circulation
Lipid metabolism pathway
Fatty acid biosynthesis
Fatty acid beta-oxidation
Fatty acid and lipoprotein transport in hepatocytes
Neurotransmitter disorders
Non-small cell lung cancer
Wnt signaling in kidney disease
Regucalcin in proximal tubule epithelial kidney cells
Pleural mesothelioma
Matrix metalloproteinases
Post-COVID neuroinflammation
Parkinson's disease pathway
Immune response to tuberculosis
Medium
Confidence score
High
Low
-
Responsive
Causative/responsive
Other
Causative
-
other
0
Cluster
1
2
0
0.5
1
1.5
2
Color
plotly-logomark